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Acute leukaemias (acute lymphoblastic leukaemia - ALL and acute myelogenous leukaemia - AML), lymphomas and a number of solid tumors.
Metastatic adenocarcinoma of the breast, carcinoma of the bladder, bronchogenic carcinoma and neuroblastoma.
Metastatic thyroid carcinoma. Carcinoma of the endometrium, testes, prostate, cervix, head and neck, and plasma-cell myeloma.
It is active against carcinoma of the ovary when administered with cisplatin and cyclophosphamide.
Concurrently with other cytotoxic drugs when administered for carcinoma of the breast and small (oat)-cell carcinoma of the lung.
Wide range of sarcomas including osteogenic, Ewing's and soft-tissue sarcoma.
In the ABVD (doxorubicin/bleomycin/vinblastin/dacarbazine) combination it is effective in Hodgkin's disease.
Concurrently in the BACOP combination in non-Hodgkin's lymphomas.
